HR: 0830h
AN: H21D-0832    [PDF]
TI: Determination of Time Dependent Virus Inactivation Rates
AU: * Chrysikopoulos, C V
EM: costas@eng.uci.edu
AF: University of California, Department of Civil and Environmental Engineering, Irvine, CA 92697 United States
AU: Vogler, E T
EM: vogler@eng.uci.edu
AF: University of California, Department of Civil and Environmental Engineering, Irvine, CA 92697 United States
AB: A methodology is developed for estimating temporally variable virus inactivation rate coefficients from experimental virus inactivation data. The methodology consists of a technique for slope estimation of normalized virus inactivation data in conjunction with a resampling parameter estimation procedure. The slope estimation technique is based on a relatively flexible geostatistical method known as universal kriging. Drift coefficients are obtained by nonlinear fitting of bootstrap samples and the corresponding confidence intervals are obtained by bootstrap percentiles. The proposed methodology yields more accurate time dependent virus inactivation rate coefficients than those estimated by fitting virus inactivation data to a first-order inactivation model. The methodology is successfully applied to a set of poliovirus batch inactivation data. Furthermore, the importance of accurate inactivation rate coefficient determination on virus transport in water saturated porous media is demonstrated with model simulations.
DE: 1800 HYDROLOGY
DE: 1829 Groundwater hydrology
DE: 1831 Groundwater quality
DE: 1832 Groundwater transport
SC: Hydrology [H]
MN: 2003 Fall Meeting